||Solubility, Bioavailability, Powder Flow, Compaction, Compression, Dissolution, Downstream Manufacturing Efficiencies
||Magnesium stearate as a lubricant in tablet production and its effective lubricity can be correlated to tablet ejection forces. Magnesium stearate batches with a smaller particle size distribution and larger surface area produces increased lubricity when compared with batches of larger particle size and smaller surface area.
||Bioavailability, Compaction, Powder Flow, Dissolution
||The principle used by Laser Diffraction assumes all particles arespheres. In practice, when irregularly-shaped particles are present in greater degrees, the DLS particle size may be erroneous and this could prevent a proper assessment of bioavailability/dissolution downstream, as well as compaction and flow.
||Dissolution, Solubility Compaction
||Increasing surface area may improve solubility and dissolution, hence a control parameter for proper dosage/bioavailability. Surface area also plays a significant role in material flow and bonding properties.
||True Density, Roller Compaction-Lubrication Tableting Setting, Segregation, Compaction, Crystallinity
||Knowing the density distributions in the ribbons is very important in improving the effectiveness of the roller compaction process and the granules produced for milling. Other applications include tablet void volume and predicting material segregation. Blends with varying particle densities may require special handling.
||Roller Compaction, Tablet Strength (physical), Fragmentation, Compaction, Content Uniformity/Dissolution
||Porosity measurement can evaluate the ability of liquids to penetrate the tablet for dissolution assessment. Can assist in parameter setting for material flow in coating operations. Predictive evaluation for pellet deformation during compression. Total pore volume and percent porosity for roller compacts.