Adaptive Correlation, M3-PALS and constant current zeta mode, with easy to use software and data quality feedback.
All incorporated into a compact, user-friendly instrument.
DLS analysis : particle size measurements from 0.3 nm to 10 μm
Zeta potential of nanoparticles and colloids using M3-PALS analysis and constant current zeta mode
Molecular weight using Static Light Scattering at 90°
Supports use of Low Volume Disposable Capillary Cell for size measurements in sample volumes as low as 3 μL
Extended size range analysis offers improved accuracy for particle sizes above 1 μm, and indicative results above 10 μm (using ZSU1002 Low Volume Disposable Sizing Cell)
On-site upgradeability to either Zetasizer Pro or Zetasizer Ultra models
Like other Zetasizer Advance systems, the Ultra pairs seamlessly with Sample Assistant for automation and OmniTrust for data integrity. That’s accuracy, automation and integrity, all in one workflow, so you can move projects forward with confidence.
You’ll see multimodal samples resolved with precision, with every measurement automatically optimized by Adaptive Correlation and high-resolution results delivered by our patented multi-angle dynamic light scattering (MADLS) technology.
When samples are unstable, polydisperse, or just plain difficult, other dynamic light scattering systems struggle. Zetasizer Ultra cuts through the noise to give you clear, high-resolution data, fast.
The Zetasizer is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties.
Variations in molecule concentration, external temperature, level of agitation, and time all impact the stability of biological molecules. Instabilities mainly result in denaturation and aggregation of the molecule, through which they can lose their biological function, elicit an immune response, and consequently limit their therapeutic viability. Factors affecting therapeutic efficacy and immunogenicity, therefore, need to be monitored throughout the development pipeline, especially at early stages, to de-risk the biological drug molecule and limit late-stage failures. The Zetasizer range provides high-quality, stability-indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.
Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.
Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behavior.
Paint, ink and coating formulations must be stable to keep them in an optimum state over time without change or aggregation. Particle size and zeta potential, measured by the Zetasizer instruments, play important roles in determining a product’s properties, such as dispersibility, color, strength, finish, durability and shelf life.
The correct particle size and zeta potential can help ensure the production of effective therapeutics, delivered safely. Zetasizer systems are used to characterize the stability and quality of dispersions, emulsions and creams, reducing formulation time and speeding new products to market.
Ensure system access and records are secure, consistent, and easy to review for 21 CFR Part 11 with OmniTrust - our compliance solution for regulated environments.
Regulated environmentOmniTrust is Malvern Panalytical’s multi-instrument solution for regulatory compliance and data integrity.
OmniTrust gives you peace of mind by providing robust regulatory compliance and data integrity, reducing the administrative burden on users. It streamlines workflows and is designed to be user-friendly, making it easy to implement and use on a daily basis.
For protein researchers, early access to characterization data can be a challenge, due to low sample volumes. This is easily overcome using the Zetasizer Lab with the capillary cell to confirm that samples meet quality requirements and that production and purification processes are optimized.
Monitoring viral concentration is important during development and production optimization. By using the Multi-Angle DLS (MADLS) based particle concentration measurement in the Zetasizer Ultra, both the size distribution and titer of the virus can be measured within a few minutes.
Photoluminescent C-dots are considered safer alternatives to quantum dots. Measuring fluorescent samples by DLS can be challenging due to additional photons emitted by the fluorophore. Available with NIBS on Zetasizer Pro, a filter removes this interference to provide accurate and reliable data.
The strength of ceramics is linked to particle size, and the Zetasizer is ideally placed to measure this. Al₂O₃ samples are often made of differently-sized particles which can easily be identified using MADLS. In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.
Titanium dioxide use is wide-ranging. When used in paints or inks, agglomerate or aggregate formation can diminish product performance. The Zetasizer Pro Blue Label, used alongside the MPT‑3 Autotitrator, characterizes the impact of salt concentration on the stability of TiO₂ and identifies the most stable pH region.
Sizing of colloidal silica is a critical requirement. This is easily and reproducibly measured using the Zetasizer.
Proven in laboratories worldwide through customer experience and supported by thousands of scientific publications and citations.
Malvern Panalytical instruments are built to last and good maintenance and care ensure continued peak performance for many years to come.
SupportClick the links below to learn more about our support and aftercare options:
| Measurement principle | Classical 90° Dynamic Light Scattering |
|---|---|
| Measurement angle | 90°, 13° 1 |
| Measurement range | 0.3 nm - 15 μm 2 |
| Minimum sample volume | 3 μL |
| Concentration range | Minimum Sample Concentration:
Blue Label: 1 mg/mL 15 kDa Protein
Red Label: 0.3 mg/mL 15 kDa Protein
Maximum sample Concentration: 3
40% w/v
|
| Measurement principle | Mixed-Mode Measurement phase analysis light scattering (M3-PALS) |
|---|---|
| Size range | 3.8 nm – 100 μm |
| Minimum sample volume | 20 μL 4 |
| Concentration range | Red Label: 1 mg/mL 5 to 40% w/v 6
Blue Label: 10 mg/mL 5 to 40% w/v 6 |
| Sample conductivity range | Maximum: 260 mS/cm |
| Measurement principle | Static Light Scattering with Debye Plot |
|---|---|
| Molecular weight range | Lab – Red Model: 300 Da - 20 MDa
Lab – Blue Model: 980 Da - 20 MDa |
| Accuracy | +/- 10% |
| Detector | Avalanche Photodiode |
|---|---|
| Laser safety | He-Ne (633 nm)
Blue label: 4 mW Max
Red label: 10 mW Max |
| Temperature control range | 0 °C - 120 °C 7 |
| Dimensions (W, D, H) | 322 mm x 565 mm x 245 mm |
| Weight | 19 kg |
| Power | AC 100-240 V, 50-60 Hz, 4.0 A |
| Power consumption | Max 100 W, Typical 45 W |
| Ambient conditions | +10°C to +35°C, 35 to 80% RH (Non-condensing) |
| Interface | USB 2.0 or higher |
| International standards | International Standards Organization
ISO22412:2025 ISO13099-2:2025
US Pharmacopoeia (USP)
430 - Particle Size Analysis by Dynamic Light Scattering
432 - Determination of Zeta Potential by Electrophoretic Light Scattering
729 - Globule Size Distribution in Lipid Injectable Emulsions
1153 - Drug Products Containing Nanomaterials
1154 - Liposome Drug Products
1430 - Analytical Methodologies Based on Scattering Phenomena - General
ASTM
D4001
E2490
E2865
E3247 |
| Notes | 1 - Water as dispersant
2 - Indicative data available for particle sizes greater than 10 μm when using Extended Size Range analysis and low volume disposable sizing cell accessory
3 - Sample dependent
4 - Using patented diffusion barrier technique
5 - Measured using 15 kDa protein
6 - Measured using bile acid
7 - Dry nitrogen cell purge required for temperatures below dewpoint
8 - Accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C |
|---|
Zetasizer's extensive range of enhancements and cell/cuvette options are designed to maximise your systems performance, flexibility and efficiency, with each component ensuring smooth operation, accurate results and easy adaptation to your analytical workflow.
Empowering scientists, one automated test at a time
Viscosity measurement with speed, simplicity and accuracy.
Automate your pH titrations
Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell.
Reusable solvent resistant cell.
Save time and effort by measuring zeta potential with little or no dilution.
Glass cuvette for use with dip cell
Glass cuvette for batch measurements
Disposable polystyrene cuvettes
Low-volume quartz batch cuvette for size and molecular weight measurements.
Adaptive Correlation, M3-PALS and constant current zeta mode, with easy to use software and data quality feedback. All incorporated into a compact, user-friendly instrument.
Request a quote or talk to an expert for more information
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