Zetasizer Pro

High performance, versatile and robust

Overview

The new Zetasizer Pro is your go-to instrument to measure a wide range of sample types and concentrations. It offers wide dynamic concentration capability and high sensitivity due to the Non-Invasive Back Scatter (NIBS) optical design. Measurement of particle sizemolecular size, electrophoretic mobility, zeta potential and molecular weight can all be performed with ease.

The Adaptive Correlation feature enhances sample throughput by reducing measurement duration and providing greater sample knowledge. The deep learning-based data quality system gives you the confidence to know your data is the best it can be.

The optical filter wheel allows measurement of fluorescent samples without impacting overall instrument sensitivity.

Specification

Particle size and molecular size

Measurement principle
Non-Invasive Back Scatter (NIBS) 
Dynamic Light Scattering
Measurement angle 173°, 13°
Measurement range 0.3 nm - 10 μm
Minimum sample volume 12 μL
Concentration range
Minimum sample concentration: 
Blue Label: 0.2 mg/mL 15 kDa Protein
Red Label: 0.1 mg/mL 15 kDa Protein
 
Maximum sample concentration: (3)
40% w/v 

Zeta potential

Measurement principle Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
Size range 3.8 nm – 100 μm
Minimum sample volume 20 μL
Concentration range
Red Label: 1 mg/mL (5) to 40% w/v (6)
Blue Label: 10 mg/mL (5) to 40% w/v (6)
Sample conductivity range Maximum: 260 mS/cm

Static Light Scattering (molecular weight)

Measurement principle Static Light Scattering with Debye Plot
Molecular weight range 300 Da - 20 MDa
Accuracy +/- 10%

System

Detector Avalanche Photodiode
Laser safety
He-Ne (633 nm)
Blue label: 4 mW Max 
Red label: 10 mW Max
Temperature control range 0 °C - 120 °C 7
Dimensions (W, D, H) 322 mm x 565 mm x 245 mm
Weight 19 kg
Power AC 100-240 V, 50-60 Hz, 4.0 A
Power consumption Max 100 W, Typical 45 W
Ambient conditions +10°C to +35°C, 35 to 80% RH (Non-condensing)
Interface USB 2.0 or higher

Notes

Notes
1 - Water as dispersant
2 - Indicative data available for particle sizes greater than 10 μm when using Extended Size Range analysis and low volume disposable sizing cell accessory
3 - Sample dependent
4 - Using patented diffusion barrier technique
5 - Measured using 15 kDa protein
6 - Measured using bile acid
7 - Dry nitrogen cell purge required for temperatures below dewpoint 
8 - Accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C

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