The new Zetasizer Ultra is our most advanced system for the measurement of particle and molecular size, particle charge and particle concentration, and represents the most intelligent and flexible instrument in the Zetasizer Advance range.
Our flagship model enjoys all the benefits afforded by ZS Xplorer software, in terms of ease of use, analysis speed and data confidence, and also offers two unique measurement capabilities: Multi-Angle Dynamic Light Scattering (MADLS) and particle concentration*, to offer even greater insight into your samples.
*Zetasizer Ultra Red Label only
The Zetasizer Ultra is the world’s most capable combined DLS and ELS system, incorporating Non-Invasive Back Scatter (NIBS) and, uniquely, Multi-Angle Dynamic Light Scattering (MADLS) technology for the measurement of particle and molecular size.
NIBS provides the versatility and sensitivity to measure over a wide concentration range, while MADLS permits a higher resolution view into your sample’s size distribution for those critical measurements.
A unique capability of the Zetasizer Ultra Red Label allows the measurement of particle concentration - suitable for a wide range of materials, requires no or little dilution, and is quick to use – ideal as a screening technique. This can even be applied to samples such as viruses and virus-like particles (VLPs), previously very challenging to measure.
A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume and concentration, including the new low-volume disposable sizing cell kit. This offers the dual benefits of size measurements in as little as 3 µL, and extension to the upper size range of DLS measurements, due to the suppression of convection currents.
Works with OmniTrust: Malvern Panalytical's compliance solution for the regulated environment
M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements
Adaptive Correlation for faster, more reproducible sizing measurements with less sample preparation
ZS Xplorer software suite for simple and flexible method set-up and data analysis
The optional MPT-3 Autotitrator enables study of the effect of changes in pH
Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
New Sample Assistant accessory reduces time manually changing samples, without compromising data quality
Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity. Also includes polarization filters for DDLS measurements
Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 µL) analysis, with an upper size range that extends to 10 μm
Key measurement capabilities include:
| Zetasizer Ultra | Zetasizer Pro | Zetasizer Lab | |
|---|---|---|---|
| Size Measurement Principle | Non-Invasive Back Scatter (NIBS)
Dynamic Light Scattering Dynamic Light Scattering (90° and 13°) Multi-Angle Dynamic Light Scattering (MADLS®) |
Non-Invasive Back Scatter (NIBS)
Dynamic Light Scattering |
Classical 90° Dynamic Light Scattering |
| Zeta Measurement Principle | ELS with M3-PALS and Constant Current Zeta Mode | ELS with M3-PALS and Constant Current Zeta Mode | ELS with M3-PALS and Constant Current Zeta Mode |
| Molecular Weight and B22 | Static Light Scattering (90° and 173°) | Static Light Scattering (173°) | Static Light Scattering (90°) |
| Optical Filter Wheel (Fluorescence/DDLS) | Yes | Yes | No |
| Low Volume Disposable Sizing Cell with Extended Size Analysis Support | Yes | No | Yes |
| MADLS® (High Resolution DLS) | Yes | No | No |
| MADLS® - Particle Concentration/Titer | Yes2 | No | No |
| 21 CFR Part 11 compliant software | Optional via Omnitrust | Optional via Omnitrust | Optional via Omnitrust |
| Size | |||
| Range2 | 0.3 nm to 10 μm | 0.3 nm to 10 μm | 0.3 nm to 10 μm |
| Minimum Volume | 3 μL | 12 μL | 3 μL |
| Zeta potential | |||
| Size Range | 3.8 nm to 100 μm | 3.8 nm to 100 μm | 3.8 nm to 100 μm |
| Minimum Volume3 | 20 μL | 20 μL | 20 μL |
1 Red Label only
2 10 um by default. Option to extend for Zetasizer Lab and Zetasizer Ultra coming soon
3 Patented Diffusion Barrier method in capillary cell
The Zetasizer Advance Range is suitable for a wide range of applications, including:
Sizing of colloidal silica is a critical requirement. This is easily and reproducibly measured using the Zetasizer Lab Blue Label.
Titanium dioxide use is wide-ranging. When used in paints or inks, agglomerate or aggregate formation can diminish product performance. The Zetasizer Pro Blue Label, used alongside the MPT‑3 Autotitrator, characterizes the impact of salt concentration on the stability of TiO2 and identifies the most stable pH region.
The strength of ceramics is linked to particle size, and the Zetasizer Ultra Blue Label is ideally placed to measure this. Al2O3 samples are often made of differently-sized particles which can easily be identified using MADLS. In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.
For protein researchers, early access to characterization data can be a challenge, due to low sample volumes. This is easily overcome using the Zetasizer Lab Red Label with the capillary cell to confirm that samples meet quality requirements and that production and purification processes are optimized.
Photoluminescent C-dots are considered safer alternatives to quantum dots. Measuring fluorescent samples by DLS can be challenging due to additional photons emitted by the fluorophore. Available with NIBS on Zetasizer Pro Red Label, a filter removes this interference to provide accurate and reliable data.
Monitoring viral concentration is important during development and production optimization. By using the Multi-Angle DLS (MADLS) based particle concentration measurement in the Zetasizer Ultra Red Label, both the size distribution and titer of the virus can be measured within a few minutes.
The Zetasizer Advance Range is used in many industries, including:
The Zetasizer Lab is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties.
Variations in molecule concentration, external temperature, level of agitation and time all impact the stability of biological molecules. Instabilities mainly result in denaturation and aggregation of the molecule through which they can lose their biological function , elicit an immune response and consequently limit its therapeutic viability. Factors affecting therapeutic efficacy and immunogenicity therefore need to be monitored throughout the development pipeline especially at early stages to de-risk the biological drug molecule and limit late-stage failures. The Zetasizer range provides high quality, stability indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.
Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.
Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behavior.
Paint, ink and coating formulations must be stable to keep them in an optimum state over time without change or aggregation. Particle size and zeta potential, measured by the Zetasizer instruments, play important roles in determining a product’s properties, such as dispersibility, color, strength, finish, durability and shelf life.
The correct particle size and zeta potential can help ensure the production of effective therapeutics, delivered safely. Zetasizer systems are used to characterize the stability and quality of dispersions, emulsions and creams, reducing formulation time and speeding new products to market.
Excellent system for characterizing nanoparticles in terms of their Physicochemical properties (size, concentration, polydispersity, and zeta potential). I like the system because it consumes only a few microliters of precious samples to determine and analyze all the properties mentioned above. I highly recommend this system for particle analysis."
Ashwini Mishra — AAVinue Inc.
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