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Zetasizer Ultra

World’s most advanced light scattering system

Overview

The new Zetasizer Ultra is our most advanced system for the measurement of particle and molecular size, particle charge and particle concentration, and represents the most intelligent and flexible instrument in the Zetasizer Advance range.

Our flagship model enjoys all the benefits afforded by ZS Xplorer software, in terms of ease of use, analysis speed and data confidence, and also offers two unique measurement capabilities: Multi-Angle Dynamic Light Scattering (MADLS) and particle concentration*, to offer even greater insight into your samples.

*Zetasizer Ultra Red Label only

Overview

When samples are unstable, polydisperse, or just plain difficult, other dynamic light scattering systems struggle. Zetasizer Ultra cuts through the noise to give you clear, high-resolution data, fast. 

You’ll see multimodal samples resolved with precision, with every measurement automatically optimized by Adaptive Correlation and high-resolution results delivered by our patented multi-angle dynamic light scattering (MADLS) technology. 

Like other Zetasizer Advance systems, the Ultra pairs seamlessly with Sample Assistant for automation and OmniTrust for data integrity. That’s accuracy, automation and integrity, all in one workflow, so you can move projects forward with confidence.

Features that deliver results

  • One platform, three critical answers : size, concentration, and zeta potential (Zetasizer Ultra also measures molecular weight).

  • Adaptive Correlation tailors each run to your sample’s behavior, reducing noise and delivering accurate data up to three times faster than traditional DLS.

  • ZS Xplorer software guides you through every step of analysis, to ensure high-quality data – even when the user isn’t a light scattering expert.

  • Machine learning-powered analysis detects data quality issues and gives clear, actionable advice - so you always get the best data from every sample.

  • Patented multi-angle DLS ( MADLS ) technology delivers 2:1 resolution size and concentration in minutes.

  • Pair with Zetasizer Sample Assistant  to automate your measurements and increase system usage threefold. 

  • Low volume sizing cell delivers accurate data from just 1 µL — ideal for scarce or high-value materials.

  • Sample options: From complex biological samples (like proteins and viruses) to ceramics and carbon dots, the Ultra handles it all.

Dive deeper with these free resources

Key applications

Zetasizer Ultra is ideal for a wide range of applications across many industries, including pharmaceuticals and mining. Find out more below about the key applications for Zetasizer Ultra.

Lipid nanoparticles

Zetasizer Ultra provides rapid, reliable characterization of lipid nanoparticles and viral vectors.

Measure particle size, concentration, polydispersity, and zeta potential to assess stability, yield, and surface charge across formulation development and manufacturing workflows to refine processes and ensure batch-to-batch reproducibility.

Viruses

Speed up analysis of viruses with fast size and concentration measurements. MADLS® technology enables simultaneous size and concentration measurement, determining viral titer and distribution in minutes.

Monitoring these key parameters with Zetasizer Ultra helps you optimize processes, maintain quality, and reduce development time.

Ceramics

The strength of ceramics is linked to particle size, and the Zetasizer Ultra is ideally placed to measure this. Al2O3 samples are often made of differently-sized particles which can easily be identified using MADLS.

In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.

Resources

Excellent system for characterizing nanoparticles in terms of their Physicochemical properties (size, concentration, polydispersity, and zeta potential). I like the system because it consumes only a few microliters of precious samples to determine and analyze all the properties mentioned above. I highly recommend this system for particle analysis."

Ashwini Mishra — AAVinue Inc.

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